Heart disease is a leading cause of death in the US today and patients that survive a myocardial infarction have a low five year survival rate. Therefore there is a great need for regenerative approaches for stimulating repair.
Gene electro transfer (GET) to the left ventricular myocardium is a promising technique for delivery of therapeutic genes for the treatment of ischemia, myocardial infarction and heart failure directly to the effected myocardium. In this study a small animal model (rat) and a large animal model (porcine) were used for gene delivery to non-ischemic and ischemic left ventricular myocardium.
Gene expression was evaluated histologically for location of expression within the myocardium as well as quantitatively via ELISA. These animal models allow for the evaluation of therapeutic potential of particular gene delivery as well as translation to clinical settings.
— From Gene Electro Transfer to Left Ventricular Myocardium in Rat and Porcine Models by A.A. Bulysheva, B. Hargrave, N. Burcus, C.G. Lundberg, L. Murray, and R. Heller.
Past studies have shown post mortem porcine tissue effective in studying bone regeneration and other human health issues.
Animal Biotech is proud to be a part of this kind of work. For over 25 years, we have helped the biomedical research community by supplying it with live high quality research porcine models as well as high quality post mortem porcine tissues, organs, and glands. Animal Biotech also supplies information, consultation and training on husbandry, testing, housing and uses of live animals. Contact us today to learn more about how we can assist you in your work.